Antibacterial and Immuno-Modulatory Roles of Ocimum Gratissimum in the Control of E. coli O157:H7 Chicken Colibacillosis

Ezeonu, I. M.; Umeoduagu, N. D.; Ikele, O. M.

Title:
Antibacterial and Immuno-Modulatory Roles of Ocimum Gratissimum in the Control of E. coli O157:H7 Chicken Colibacillosis

Authors:
Ikele, O. M. | Ezeonu, I. M. | Umeoduagu, N. D.

Cite This Article :

Ikele, O. M. | Ezeonu, I. M. | Umeoduagu, N. D. "Antibacterial and Immuno-Modulatory Roles of Ocimum Gratissimum in the Control of E. coli O157:H7 Chicken Colibacillosis" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-6, October 2022, pp.640-647, URL: https://www.ijtsrd.com/papers/ijtsrd51930.pdf

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Abstract :
O. gratissimum is one of the leafy vegetables used by Nigerians as a food additive in preparing some local dishes. It has also been documented by some researchers to have some medicinal values. This research aimed at monitoring the immunomodulatory and antibacterial roles of Ocimum gratissimum ethanolic extract in the control of colibacillosis in broilers; as a natural alternative to antibiotic therapy.1.5 ml 107 cfu/ml E. coli O157:H7 isolated from nono (sour milk) and identified with 16s rDNA sequencing, was used to elicit colibacillosis infection in three weeks old broilers. Oral administration of the plant extract (40 g/l) to the infected birds over a 1 month period resulted in regulated haemoglobin, blood electrolytes, urea, creatinine, C-reactive protein and liver enzyme values. Microbial counts in the intestine revealed a decrease in total E. coli count. Histopathology examination of the intestinal tissues revealed the activity of gut associated lymphoid tissue in immune response. O. gratissimum ethanolic extract can serve as a natural alternative to antibiotic therapy in the control of colibacillosis in broilers.

Keywords :
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Publication Details:

Unique Identification Number : IJTSRD51930

Published In : Volume-6 | Issue-6, October 2022

Page Number(s) : 640-647

Publisher Name : IJTSRD | www.ijtsrd.com | E-ISSN 2456-6470

Copyright © 2019 by author(s) and International Journal of Trend in Scientific Research and Development Journal. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0)

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